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Are Chronic Degenerative Diseases Part of the Ageing Process? : Insights from Comparative Biology

By: Michael A Singer (Edited by)

Extended Catalogue

Ksh 56,100.00

Format: Hardback or Cased Book

ISBN-10: 162618013X

ISBN-13: 9781626180130

Publisher: Nova Science Publishers Inc

Imprint: Nova Science Publishers Inc

Country of Manufacture: US

Country of Publication: GB

Publication Date: May 1st, 2013

Publication Status: Active

Product extent: 312 Pages

Weight: 574.00 grams

Dimensions (height x width x thickness): 26.10 x 18.30 x 1.80 cms

Product Classification / Subject(s): Geriatric medicine

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Most of the DNA in the human genome does not encode proteins but is involved in regulatory functions. In addition, the human genome is characterized by an extensive array of structural DNA variants arising from de novo mutations plus accumulated structural variants transmitted through an individual''s lineage. The result is that each person has a unique genome which is expressed as that person''s unique phenotype. Ageing can be understood on both the species and individual level. Each species has a programmed ageing and mortality pattern, but within those broad species-specific boundaries there is considerable individual variation. At the individual level, ageing reflects the integrated effects of that individual''s unique mix of DNA structural variants, unique experience-specific epigenetic marks and imperfectly repaired genomic and cellular damage. This book examines human "chronic degenerative" diseases which are not diseases, but rather variations of the ageing process across individuals.

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